Endocrine Abstracts

Background: Follicles imaturation, as the hallmark of polycystic ovarian syndrome caused by prenatal androgen exposure, is suspected to be effected through expression changes of related genes. The aim of this study was to evaluate gene expression and promoter methylation of GATA6 and Follistatin (FST), two factors involved in follicle maturation, in adult female rats prenatally exposed to androgen excess by comparing them with non-treated rats.Material a...

Background: Polycystic ovary syndrome (PCOS) is a frequent endocrine and metabolic disorder and the most common cause of infertility occurring in 5–10% of women of reproductive age. The characteristic endocrine abnormalities of PCOS involve hypersecretion of androgens and LH (as a consequence of increased GnRH frequency). Although PCOS signs generally become obvious at puberty, clinical and experimental evidence suggests an intrauterine origin for the syndrome. On the oth...

Introduction: Idiopathic hirsutism (IH) is one of the most frequent complaints affecting 13% of reproductive aged women. The relationship between IH and metabolic abnormalities are not fully understood. The aim of this study was to evaluate the relationship between IH and metabolic abnormalities.Methods: A total number of 100 idiopathic hirsute women (range 15–45 years) recruitment from a population based cohort study of Tehran Lipid and Glucose Stu...

Introduction: Sexual dysfunction could be under the influence of menopause and the changes it causes in hormone levels. The purpose of this study is to examine the correlation between serum levels of androgens and sexual function in post-menopausal women.Methods: This is a community-based, descriptive-analytical study involving 405 post-menopausal women, aged 40–65 years, who had reached menopause up to 3 years prior to the study. A multi-stage, ran...

Introduction: Menstrual disturbances can be considered as a sign of reproductive system disorders in women in reproductive ages. These disturbances can be indicators of serious underlying problems. The aim of this study was to determine the prevalence and pattern of menstrual related manifestation among Iranian women.Methods: This was a population-based study conducted among women (n=941) aged 18–45 years. The participants who met the eligi...

Introduction: The prevalence of these disorders in pregnant women is relatively high and may affect mother and foetus adversely if they are not evaluated and treated appropriately. Therefore, their diagnosis and treatment is very important. On the other signs and symptoms of thyroid disease can often be masked by the physiologic changes of pregnancy and are not found. The aim of this study was to evaluate the physiological symptoms similar to thyroid disorders and their incide...